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Trigun's designs and especially manga incarnation are heavily influenced by McFarlane. ∀ Gundam's mechanical designs by Syd Mead. Usavich Obscure series Montana Jones resembles a series from The Disney Afternoon such as Adventures of the Gummi Bears, TaleSpin, or Timon & Pumbaa. Cowboy Bebop draws on influences from a variety of genres, many of them quite western (including The Western, appropriately enough), down to featuring one planet themed around Blaxploitation movies. Baby Felix was produced by a Japanese studio with input from former Felix the Cat owner Don Oriolo, and is anime trying (and often failing) to look like Western Animation. The character designs from Zoobles seem to be at least slightly influenced by stuff like My Little Pony: Friendship Is Magic and Littlest Pet Shop (2012), which themselves are very animesque.
But in its core, One Piece is about something else: it's about nakama. Nakama, a Japanese term generally referring to comrades, receives a completely new feeling in One Piece. Stand by your nakama, believe in them no matter what happens, no matter what anyone does or says about them. Help them in any situation, even if it means putting your own life on the line. With you nakama, you can do anything. And it is this extreme sense of comradry that makes you fall in love with the characters and wish you could be a part of the strange little group.
It also teaches how humans are allowed to have flaws; in fact, all people do: seemingly perfect Swordsman and first mate Roronoa Zoro has no sense of direction whatsoever and can easily get himself lost on any one way street, navigator Nami is absolutely crazy for money, cook Sanji loses his mind once he sees a lady. and the list goes on and on. But despite these flaws, they continue fighting. For each other and with each other.