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Attemptees of human transmutation are also thrown into the Gate of Truth (真理の扉, Shinri no Tobira), where they receive an overwhelming dose of information, but also allowing them to
transmute without a circle. All living things possess their own Gate of Truth, and per the Gaea hypothesis, heavenly bodies like planets also have their own Gates of Truth. It is possible to bypass the Law of Equivalent Exchange using a Philosopher's Stone, a red, enigmatic substance. Philosopher's Stones are used to create Homunculi, artificial humans of proud nature who are named after and embody the seven deadly sins; Homunculi have numerous superhuman abilities
unique among each other, and look down upon all humanity. With the exception of one, they do not age and can only be killed via the destruction of their Philosopher's Stones. There are several cities throughout Amestris. The main setting is the capital of Central City (セントラルシティ, Sentoraru Shiti), along with other military cities such as the northern city of Briggs (ブリッグズ, Burigguzu). Towns featured include Resembool (リゼンブール, Rizenbūru), the rural hometown of the Elrics; Liore (リオール, Riōru), a city tricked into following a cult; Rush Valley (ラッシュバレー, Rasshu Barē), a town that specializes in automail manufacturing; and Ishbal, a conservative-religion region that rejects alchemy and was destroyed in the Ishbalan Civil War instigated after a soldier shot an Ishbalan child. Outside of Amestris, there are few named countries, and none are seen in the main story. The main foreign country is Xing. Heavily reminiscent of China, Xing has a complex
system of clans and emperors, as opposed to Amestris's government-controlled election of a Führer.
Kagetoki challenges them to fight, and Fuu is attacked by the assassins. 25"Evanescent Encounter (Part 2)"
Transliteration: "Circle of Transmigration 2 / Shōji Ruten sono ni" (Japanese: 生死流転 其之弐)Kazuto Nakazawa[8]Shinichirō Watanabe, Shinji Obara[8]March 12, 2005 (2005-03-12)March 2, 2006 Mugen and Kagetoki fight, with Mugen being easily defeated, and Denkibou
arriving to tell Mugen and Jin to go to the church on Ikitsui to save Fuu. Jin tells Mugen to go, and Kariya Kagetoki expresses interest in killing the samurai who killed Enshiro Mariya, Jin's teacher. It is revealed
that Jin killed his master after Kagetoki persuaded Mariya to turn his students into assassins and later ordered Mariya to kill Jin. Kagetoki and Jin fight again, with Kagetoki seemingly killing Jin. Meanwhile, Denkibou attacks Mugen on the boat to Ikitsui, and Mugen kills him while being gravely injured.
However, Bundai takes the brothers away. 19"Unholy Union"
Transliteration: "Karma and Retribution / Ingaōhō" (Japanese: 因果応報)Hirotaka Endo[8]Seiko Takagi[8]January 29,
2005 (2005-01-29)January 19, 2006 Fuu is waiting for Jin and
Mugen in a shed when a young woman name Yuri barges in, trying to hide from a charlatan name Xavier III who pretends to be Christian so he can get weapons. Yuri notices the necklace Fuu wears, and confirms it to be a Christian symbol. Xavier's thugs break in the shed, knocking out Fuu and kidnapping Yuri. While the trio try to find Yuri, Fuu is caught, and Yuri reveals that the sunflower samurai's name is Seizo Kasumi. Mugen and Jin expose Xavier III as a fraud, and while trying to escape Xavier III accidentally kills himself. The next morning, the trio say farewell to Yuri; Fuu then reveals that the sunflower samurai is her father. They begin travelling to Ikitsuki to find him. 20"Elegy of Entrapment (Verse 1)"
Transliteration: "Generous Elegy 1 / Hikakōgai sono ichi" (Japanese: 悲歌慷慨 其之壱)Takeshi Yoshimoto[8]Shinji Obara[8]February 5, 2005 (2005-02-05)January 26, 2006 Fuu, Mugen and Jin meet a blind woman, a travelling musician named Sara. Because of her blindness, she is able to sense the emotions of the group. During their travels, the trio grow close to Sara, especially Mugen.